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KMID : 0364219830260040283
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Korean Journal of Zoology
1983 Volume.26 No. 4 p.283 ~ p.294
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Effects of 4-Nitroquinoline-1-oxide on Synthetic Patterns of Protein and Glycosaminoglycan during Chick Development
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Hah Jae-Chung
Han Bog-Key
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Abstract
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In order to study the change of protein synthesis in developing chick embryo under the influence of carcinogenic substances, we introduced a kind of potent carcinogen, 4-nitroquinoline-1-oxide (4 NQO) to the yolk sac of developing chick embryo. There are changes of synthetic pattern of protein abreast with proceeding of development is each tissue. Protein synthesis in samples which was treated with 4NQO was decreased as compared with untreated control samples. There are tissue specificity in 4NQO effect, showing the apparent decreasing at the 24 hr after drug treatment in the lung and gizzard muscle but not in heart muscle. The results in the present study suggested that 4NQO treated samples was decreased as compared with control samples. From the above data we could know that 4NQO also affected the synthesis of glycosaminoglycan.
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